Genetic variations in the receptor-ligand pair CCR5 and CCL3L1 are important determinants of susceptibility to Kawasaki disease.

@article{Burns2005GeneticVI,
  title={Genetic variations in the receptor-ligand pair CCR5 and CCL3L1 are important determinants of susceptibility to Kawasaki disease.},
  author={Jane C. Burns and Chisato Shimizu and Enrique Perez Gonzalez and Hemant Kulkarni and Sukeshi R Patel and Hiroko Shike and Robert S Sundel and Jane W. Newburger and Sunil K. Ahuja},
  journal={The Journal of infectious diseases},
  year={2005},
  volume={192 2},
  pages={344-9}
}
Kawasaki disease (KD) is an enigmatic, self-limited vasculitis of childhood that is complicated by development of coronary-artery aneurysms. The high incidence of KD in Asian versus European populations prompted a search for genetic polymorphisms that are differentially distributed among these populations and that influence KD susceptibility. Here, we demonstrate a striking, inverse relationship between the worldwide distribution of CCR5- Delta 32 allele and the incidence of KD. In 164 KD… CONTINUE READING
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Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression

  • S Mummidi, SS Ahuja, E Gonzalez
  • Nat Med
  • 1998
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