Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma.

@article{Lin2010GeneticVI,
  title={Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma.},
  author={Jie Lin and Yohei Horikawa and Pheroze Tamboli and Jessica Clague and Christopher G Wood and X ianchao Wu},
  journal={Carcinogenesis},
  year={2010},
  volume={31 10},
  pages={1805-12}
}
We took a polygenic approach to evaluate the effects of 41 potentially functional single-nucleotide polymorphisms (SNPs) in microRNAs (miRNAs)-related genes on survival and recurrence among renal cell carcinoma (RCC) patients. During a median follow-up of 21.8 months, among 316 RCC patients, 64 died and 56 developed recurrence. In single-SNP analysis, we identified seven SNPs significantly associated with RCC survival and five SNPs with recurrence. The most significant associations were SNPs in… CONTINUE READING

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As the first study of miRNA - related genetic polymorphisms on RCC clinical outcome , our results strongly suggested that miRNA - related SNPs may impact the recurrence and survival in RCC patients .
As the first study of miRNA - related genetic polymorphisms on RCC clinical outcome , our results strongly suggested that miRNA - related SNPs may impact the recurrence and survival in RCC patients .
We took a polygenic approach to evaluate the effects of 41 potentially functional single - nucleotide polymorphisms ( SNPs ) in microRNAs ( miRNAs)-related genes on survival and recurrence among renal cell carcinoma ( RCC ) patients .
We took a polygenic approach to evaluate the effects of 41 potentially functional single - nucleotide polymorphisms ( SNPs ) in microRNAs ( miRNAs)-related genes on survival and recurrence among renal cell carcinoma ( RCC ) patients .
As the first study of miRNA - related genetic polymorphisms on RCC clinical outcome , our results strongly suggested that miRNA - related SNPs may impact the recurrence and survival in RCC patients .
As the first study of miRNA - related genetic polymorphisms on RCC clinical outcome , our results strongly suggested that miRNA - related SNPs may impact the recurrence and survival in RCC patients .
We took a polygenic approach to evaluate the effects of 41 potentially functional single - nucleotide polymorphisms ( SNPs ) in microRNAs ( miRNAs)-related genes on survival and recurrence among renal cell carcinoma ( RCC ) patients .
As the first study of miRNA - related genetic polymorphisms on RCC clinical outcome , our results strongly suggested that miRNA - related SNPs may impact the recurrence and survival in RCC patients .
As the first study of miRNA - related genetic polymorphisms on RCC clinical outcome , our results strongly suggested that miRNA - related SNPs may impact the recurrence and survival in RCC patients .
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