Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.

@article{Ye2008GeneticVI,
  title={Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.},
  author={Yuanqing Ye and Kenneth K. Wang and Jian Gu and Hushan Yang and Jie Lin and Jaffer A. Ajani and Xifeng Wu},
  journal={Cancer prevention research},
  year={2008},
  volume={1 6},
  pages={460-9}
}
MicroRNAs (miRNA) can act as oncogenes or tumor suppressors and modulate the expression of approximately one third of all human genes. To test the hypothesis that adverse alleles in miRNA-related genes may increase the risk for esophageal cancer, we assessed the associations between esophageal cancer risk and 41 potentially functional single nucleotide polymorphisms (SNP) in 26 miRNA-related genes in a case-control study of 346 Caucasian esophageal cancer patients (85.5% with esophageal… CONTINUE READING
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