Genetic variations in NALP1 are associated with generalized vitiligo in a Romanian population.

@article{Jin2007GeneticVI,
  title={Genetic variations in NALP1 are associated with generalized vitiligo in a Romanian population.},
  author={Ying Jin and Stanca Ariana Birlea and Pamela R. Fain and Richard A. Spritz},
  journal={The Journal of investigative dermatology},
  year={2007},
  volume={127 11},
  pages={2558-62}
}
Generalized vitiligo is a common, multifactorial, polygenic disease in which autoimmune loss of melanocytes results in depigmented spots of skin, overlying hair, and mucous membranes. In Caucasian families from the United States of America and United Kingdom, susceptibility to generalized vitiligo and associated autoimmune diseases is genetically associated with variants of NALP1, encoding NACHT leucine-rich repeat protein 1. Here, we describe a population-based case-control association… CONTINUE READING
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