Genetic variations in MyD88 adaptor-like are associated with atopic dermatitis.

  title={Genetic variations in MyD88 adaptor-like are associated with atopic dermatitis.},
  author={Yang Soo An and Hidenori Ohnishi and Eiko Matsui and Michinori Funato and Zenichiro Kato and Takahide Teramoto and Hideo Kaneko and Takeshi Kimura and Kazuo Kubota and Kimiko Kasahara and Naomi Kondo},
  journal={International journal of molecular medicine},
  volume={27 6},
Toll-like receptors (TLRs) are important pathogen-associated molecular pattern recognition receptors involved in initiating immune responses. The adaptor protein MyD88 adaptor-like (Mal), involved in signaling downstream of TLRs, plays a crucial role in mediating NF-κB activation. The association of Mal polymorphisms with allergic diseases has not previously been defined. The objective of this study was to detect polymorphisms in the Mal gene and to investigate their association with allergic… CONTINUE READING
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