Genetic variations in HLA-B region and hypersensitivity reactions to abacavir

  title={Genetic variations in HLA-B region and hypersensitivity reactions to abacavir},
  author={S. Hetherington and A. Hughes and M. Mosteller and D. Shortino and A. Roses},
  journal={The Lancet},
  • S. Hetherington, A. Hughes, +2 authors A. Roses
  • Published 2002
  • Biology, Medicine
  • The Lancet
  • Hypersensitivity to abacavir affects about 4% of patients who receive the drug for HIV-1 infection. We did a retrospective, case-control study to identify multiple markers in the vicinity of HLA-B associated with hypersensitivity reactions. HLA-B57 was present in 39 (46%) of 84 patients versus four (4%) of 113 controls (p<0 small middle dot0001). However, because of low numbers of women and other ethnic groups enrolled, these findings relate largely to white men. The lower sensitivity of HLA… CONTINUE READING
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