Genetic variation within the histamine pathway among patients with asthma--a pilot study.

@article{Raje2015GeneticVW,
  title={Genetic variation within the histamine pathway among patients with asthma--a pilot study.},
  author={Nikita Raje and Carrie A. Vyhlidal and Hongying Dai and Bridgette L Jones},
  journal={The Journal of asthma : official journal of the Association for the Care of Asthma},
  year={2015},
  volume={52 4},
  pages={
          353-62
        }
}
OBJECTIVE Histamine is an important mediator in the pathophysiology of asthma. We have previously reported that HRH1 is differentially expressed among those with asthma compared to those without asthma. Single histamine-related genes have also been associated with asthma. We aimed to evaluate known single nucleotide polymorphisms (SNPs) in genes along the histamine biotransformation and response pathway, and determine their association with asthma and HRH1 mRNA expression. METHODS We enrolled… CONTINUE READING
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