Genetic variation within the beta1-adrenergic receptor gene results in haplotype-specific expression phenotypes.

@article{Small2008GeneticVW,
  title={Genetic variation within the beta1-adrenergic receptor gene results in haplotype-specific expression phenotypes.},
  author={Kersten M Small and Jeanne Mialet-Perez and Stephen B. Liggett},
  journal={Journal of cardiovascular pharmacology},
  year={2008},
  volume={51 1},
  pages={106-10}
}
Cardiac beta1-adrenergic receptor (beta1AR) responsiveness in heart failure exhibits interindividual variation that may be attributable to polymorphisms of the intronless beta1AR gene. We sought to ascertain the polymorphisms of the full-length gene and the specific combinations of polymorphisms (haplotypes) in two reference populations. Using whole-gene transfections, we established the impact of beta1AR polymorphisms, within the context of haplotypes, on receptor expression. Fifteen… CONTINUE READING
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