Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia.

@article{Roffman2013GeneticVT,
  title={Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia.},
  author={Joshua L. Roffman and David G. Brohawn and Adam Z. Nitenson and Eric A Macklin and Jordan W. Smoller and Donald C. Goff},
  journal={Schizophrenia bulletin},
  year={2013},
  volume={39 2},
  pages={330-8}
}
Low serum folate levels previously have been associated with negative symptom risk in schizophrenia, as has the hypofunctional 677C>T variant of the MTHFR gene. This study examined whether other missense polymorphisms in folate-regulating enzymes, in concert with MTHFR, influence negative symptoms in schizophrenia, and whether total risk allele load interacts with serum folate status to further stratify negative symptom risk. Medicated outpatients with schizophrenia (n = 219), all of European… CONTINUE READING
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