Genetic variation of the heparan sulfate proteoglycan gene (perlecan gene). Association with urinary albumin excretion in IDDM patients.

@article{Hansen1997GeneticVO,
  title={Genetic variation of the heparan sulfate proteoglycan gene (perlecan gene). Association with urinary albumin excretion in IDDM patients.},
  author={Poul Martin Hansen and Tanzina Chowdhury and Torsten Deckert and Anders Hellgren and Steven C. Bain and Flemming Pociot},
  journal={Diabetes},
  year={1997},
  volume={46 10},
  pages={1658-9}
}
Both in patients with IDDM (1) and in healthy control subjects (2,3), increased urinary albumin excretion rate (AER) is associated with high relative morbidity and mortality. In IDDM patients, genetic susceptibility factors are most likely contributing to an increased AER (4,5) resulting in a cumulative incidence of nephropathy (AER >300 mg/24 h) of -30% (6). So far, candidate genes, proposed as susceptibility markers linked to abnormal albuminuria, have been identified because of the knowledge… CONTINUE READING