Genetic variation of the ghrelin signaling system in females with severe alcohol dependence.

@article{Landgren2010GeneticVO,
  title={Genetic variation of the ghrelin signaling system in females with severe alcohol dependence.},
  author={Sara Landgren and Elisabet Jerlhag and Jarmila Hallman and Lars Oreland and Lauren Lissner and Elisabeth Strandhagen and Dag Steinar Thelle and Henrik Zetterberg and K Blennow and J{\"o}rgen A. Engel},
  journal={Alcoholism, clinical and experimental research},
  year={2010},
  volume={34 9},
  pages={1519-24}
}
INTRODUCTION Central ghrelin signaling is required for the rewarding effects of alcohol in mice. Because ghrelin is implied in other addictive behaviors such as eating disorders and smoking, and because there is co-morbidity between these disorders and alcohol dependence, the ghrelin signaling system could be involved in mediating reward in general. Furthermore, in humans, single nucleotide polymorphisms (SNPs) and haplotypes of the pro-ghrelin gene (GHRL) and the ghrelin receptor gene (GHSR… CONTINUE READING