Genetic variation of pre-mRNA alternative splicing in human populations.

@article{Lu2012GeneticVO,
  title={Genetic variation of pre-mRNA alternative splicing in human populations.},
  author={Zhi-xiang Lu and Peng Jiang and Yi Xing},
  journal={Wiley interdisciplinary reviews. RNA},
  year={2012},
  volume={3 4},
  pages={581-92}
}
The precise splicing outcome of a transcribed gene is controlled by complex interactions between cis regulatory splicing signals and trans-acting regulators. In higher eukaryotes, alternative splicing is a prevalent mechanism for generating transcriptome and proteome diversity. Alternative splicing can modulate gene function, affect organismal phenotype and cause disease. Common genetic variation that affects splicing regulation can lead to differences in alternative splicing between human… CONTINUE READING
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