Genetic variation of pre-mRNA alternative splicing in human populations.

  title={Genetic variation of pre-mRNA alternative splicing in human populations.},
  author={Zhi-xiang Lu and Peng Jiang and Yi Xing},
  journal={Wiley interdisciplinary reviews. RNA},
  volume={3 4},
The precise splicing outcome of a transcribed gene is controlled by complex interactions between cis regulatory splicing signals and trans-acting regulators. In higher eukaryotes, alternative splicing is a prevalent mechanism for generating transcriptome and proteome diversity. Alternative splicing can modulate gene function, affect organismal phenotype and cause disease. Common genetic variation that affects splicing regulation can lead to differences in alternative splicing between human… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
15 Extracted Citations
76 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 15 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 76 references

Single nucleotide polymorphism at exon 7 splice acceptor site of OAS1 gene determines response of hepatitis C virus patients to interferon therapy

  • MK El Awady, MA Anany, +7 authors M El Raziky
  • J Gastroenterol Hepatol
  • 2011

Similar Papers

Loading similar papers…