Genetic variation of melatonin productivity in laboratory mice under domestication.

@article{Kasahara2010GeneticVO,
  title={Genetic variation of melatonin productivity in laboratory mice under domestication.},
  author={Takaoki Kasahara and Kuniya Abe and Kazuyuki Mekada and Atsushi Yoshiki and Tadafumi Kato},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 14},
  pages={6412-7}
}
Melatonin is a pineal hormone produced at night; however, many strains of laboratory mice are deficient in melatonin. Strangely enough, the gene encoding HIOMT enzyme (also known as ASMT) that catalyzes the last step of melatonin synthesis is still unidentified in the house mouse (Mus musculus) despite the completion of the genome sequence. Here we report the identification of the mouse Hiomt gene, which was mapped to the pseudoautosomal region (PAR) of sex chromosomes. The gene was highly… CONTINUE READING

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