Genetic variation of foot-and-mouth disease virus during persistent infection in cattle.

@article{Malirat1988GeneticVO,
  title={Genetic variation of foot-and-mouth disease virus during persistent infection in cattle.},
  author={Viviana Malirat and Paulo Andrade de Mello and B Tiraboschi and Ewald Beck and Iva Gomes and Ingrid Evelyn Bergmann},
  journal={Virus research},
  year={1988},
  volume={34 1},
  pages={
          31-48
        }
}
Genetic variation of foot-and-mouth disease virus O1 Campos has been analyzed in consecutive isolates recovered over a one- or two-year period from four cattle with experimental persistent infection. Comparisons of RNase T1 two-dimensional maps and nucleotide sequences of the VP1-coding region revealed a continual, although irregular, increase in the fixation of mutations as the infection progressed. Most changes were not conserved in consecutive isolates. These results, together with the… CONTINUE READING