Genetic variation of Porphyromonas gingivalis genes encoding gingipains, cysteine proteinases with arginine or lysine specificity.

@article{MIKOLAJCZYKPAWLINSKA1998GeneticVO,
  title={Genetic variation of Porphyromonas gingivalis genes encoding gingipains, cysteine proteinases with arginine or lysine specificity.},
  author={JOWITA MIKOLAJCZYK-PAWLINSKA and Tomasz Kordula and N Pavloff and Philip A. Pemberton and Will C. Chen and James Travis and Jan Potempa},
  journal={Biological chemistry},
  year={1998},
  volume={379 2},
  pages={205-11}
}
Porphyromonas gingivalis hemagglutinating cysteine proteinases (gingipains) are considered as important virulence factors in the development of adult periodontitis. Using Southern blot analysis it was determined that genes of three distinct but related gingipains (gingipain-R1, gingipain-R2 and gingipain-K) were present in all tested strains including HG66, ATCC 33277, W50, E-20-1, EM-3, 381, A7436, and IKG5, with a region encoding a part of the hemagglutinin domain of gingipain-R1 and… CONTINUE READING
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