Genetic variation influences immune responses in sensitive rats following exposure to TiO2 nanoparticles.

@article{Gustafsson2014GeneticVI,
  title={Genetic variation influences immune responses in sensitive rats following exposure to TiO2 nanoparticles.},
  author={{\AA} B Gustafsson and Sofia Jonasson and Thomas Sandstr{\"o}m and Johnny C. Lorentzen and Anders Bucht},
  journal={Toxicology},
  year={2014},
  volume={326},
  pages={74-85}
}
This study examines the immunological responses in rats following inhalation to titanium dioxide nanoparticles (TiO2 NPs), in naïve rats and in rats with induced allergic airway disease. The responses of two different inbred rat strains were compared: the Dark Aguoti (DA), susceptible to chronic inflammatory disorders, and the Brown Norwegian (BN), susceptible to atopic allergic inflammation. Naïve rats were exposed to an aerosol of TiO2 NPs once daily for 10 days. Another subset of rats was… CONTINUE READING