Genetic variation in the promoter region of the beta-fibrinogen gene is associated with ischemic stroke in a Japanese population.

@article{Nishiuma1998GeneticVI,
  title={Genetic variation in the promoter region of the beta-fibrinogen gene is associated with ischemic stroke in a Japanese population.},
  author={Shin-ichi Nishiuma and Kazuomi Kario and Kimikazu Yakushijin and Masanobu Maeda and Ryuzo Murai and Takefumi Matsuo and Uichi Ikeda and Kazuyuki Shimada and Masanao Matsuo},
  journal={Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis},
  year={1998},
  volume={9 4},
  pages={373-9}
}
Evidence suggests that an allelic variation in the beta fibrinogen gene may confer an increased risk of coronary artery disease and stroke. The role of the beta fibrinogen gene polymorphism and fibrinogen levels in ischemic stroke has not been determined in Japanese, who are more prone to stroke than to coronary artery disease compared with Caucasians. We investigated the associations between ischemic stroke, plasma fibrinogen level, and a HaeIII restriction fragment length polymorphism (G/A… CONTINUE READING

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