Genetic variation in the promoter region of the basic fibroblast growth factor gene.

@article{Bernek2003GeneticVI,
  title={Genetic variation in the promoter region of the basic fibroblast growth factor gene.},
  author={Michal Ber{\'a}nek and Svatava Tsch{\"o}plov{\'a} and Katerina Kankova and Vera Kuhrov{\'a} and Jiř{\'i} V{\'a}cha},
  journal={Human immunology},
  year={2003},
  volume={64 3},
  pages={374-7}
}
Basic fibroblast growth factor (bFGF) is a member of the fibroblast growth factor family that possess broad mitogenic and cell survival activities and is involved in a variety of biological processes. We investigated possible genetic polymorphism in the promoter and 5' flanking region of the bFGF gene. Polymorphism was analysed by means of heteroduplex analysis, fragments with altered mobility were sequenced. Three novel substitutions (-553T/A, -834T/A and -921C/G) were identified in the… CONTINUE READING
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