Genetic variation in the patterns of skeletal progenitor cell differentiation and progression during endochondral bone formation affects the rate of fracture healing.

@article{Jepsen2008GeneticVI,
  title={Genetic variation in the patterns of skeletal progenitor cell differentiation and progression during endochondral bone formation affects the rate of fracture healing.},
  author={K J Leni Jepsen and Christopher Price and Lee J Silkman and Fred H Nicholls and Phillip Nasser and Bin Hu and Nicole Hadi and Michael F Alapatt and Stephanie N Stapleton and Sanjeev Kakar and Thomas A. Einhorn and Louis Charles Gerstenfeld},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2008},
  volume={23 8},
  pages={1204-16}
}
These studies examined how genetic differences that regulate architectural and bone material properties would be expressed during fracture healing and determine whether any of these features would affect rates of healing as defined by regain of strength. Controlled fractures were generated in three inbred strains of mice: A/J, C57Bl/6J (B6), and C3H/HeJ (C3H). Both the A/J and B6 strains showed faster healing than the C3H strain based on regains in strength and stiffness. Strain-specific… CONTINUE READING
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Fractures of the shaft of the femur

  • SE Nork
  • Rockwood and Green ’ s Fractures in Adults
  • 2006
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