Genetic variation in the folate metabolic pathway and risk of childhood leukemia.

@article{Lightfoot2010GeneticVI,
  title={Genetic variation in the folate metabolic pathway and risk of childhood leukemia.},
  author={Tracy J Lightfoot and William T Johnston and Dan Painter and Jill Simpson and Eve Roman and Chris Skibola and Martyn Thomas Smith and James M Allan and Graham Malcolm Taylor},
  journal={Blood},
  year={2010},
  volume={115 19},
  pages={
          3923-9
        }
}
Studies of childhood leukemia and the potential etiologic role of genetic variation in folate metabolism have produced conflicting findings and have often been based on small numbers. We investigated the association between polymorphisms in key folate metabolism enzymes (MTHFR 677 C>T, MTHFR 1298 A>C, SHMT1 1420 C>T, MTR 2756 A>G, TS 1494del6, and TS 28bp repeat) in 939 cases of childhood acute lymphoblastic leukemia (ALL) and 89 cases of acute myeloid leukemia (AML) recruited into the United… CONTINUE READING

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