Genetic variation in the beta-2 adrenergic receptor is associated with chronic musculoskeletal complaints in adolescents.

@article{Skouen2012GeneticVI,
  title={Genetic variation in the beta-2 adrenergic receptor is associated with chronic musculoskeletal complaints in adolescents.},
  author={Jan Sture Skouen and Anne J Smith and Nicole M. Warrington and P B O' Sullivan and Lisa Mckenzie and Craig Edward Pennell and Leon M Straker},
  journal={European journal of pain},
  year={2012},
  volume={16 9},
  pages={1232-42}
}
BACKGROUND There is significant evidence to suggest that psychological and stress-related factors are important predictors of the onset of chronic widespread pain (CWP) and fibromyalgia (FM). The hypothalamic-pituitary-adrenal axis, together with the efferent sympathetic/adrenomedullary system, influence all body organs (including muscles) during short- and long-term threatening stimuli. The aim of this study was to investigate the relationship between genetic variants in adrenergic candidate… CONTINUE READING