Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease.

@article{Henckaerts2011GeneticVI,
  title={Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease.},
  author={Liesbet Henckaerts and Isabelle Cleynen and Marko Brinar and Jestinah M. Mahachie John and Kristel van Steen and P. R. Rutgeerts and S{\'e}verine Vermeire},
  journal={Inflammatory bowel diseases},
  year={2011},
  volume={17 6},
  pages={
          1392-7
        }
}
BACKGROUND The autophagy pathway has been linked with Crohn's disease (CD) through association of the ATG16L1 and IRGM genes with susceptibility for CD, and also to the Nod2 pathway, involved in CD. Our aim was to investigate polymorphisms in selected autophagy genes for their association with susceptibility to CD. METHODS We prioritized all known human homologs of yeast autophagy (Atg) genes according to their location in a known inflammatory bowel disease (IBD) locus or in a genomic region… CONTINUE READING