Genetic variation in the androgen receptor gene and endometrial cancer risk.

@article{Yang2009GeneticVI,
  title={Genetic variation in the androgen receptor gene and endometrial cancer risk.},
  author={Hannah Yang and Montserrat Garc{\'i}a-Closas and James V Lacey and Louise A Brinton and Jolanta Lissowska and Beta Peplonska and Stephen J. Chanock and Mia M Gaudet},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2009},
  volume={18 2},
  pages={585-9}
}
Genetic variation in the androgen receptor (AR) gene may be associated with endometrial cancer risk based on the role of AR in regulating androgen levels. However, endometrial cancer studies reported inconsistent associations for a CAG repeat polymorphism in exon 1. Only one of these studies measured haplotype-tagging single nucleotide polymorphisms (htSNP) in AR and found statistically nonsignificant, decreased associations with endometrial cancer risk. In a population-based case-control study… CONTINUE READING