Genetic variation in the TLR and NF-κB pathways and cervical and vulvar cancer risk: a population-based case-control study.

@article{Bodelon2014GeneticVI,
  title={Genetic variation in the TLR and NF-κB pathways and cervical and vulvar cancer risk: a population-based case-control study.},
  author={Clara Bodelon and M M Madeleine and Lisa Godefroy Johnson and Qin Du and Denise A. Galloway and Mari Malkki and Effie W. Petersdorf and Stephen M Schwartz},
  journal={International journal of cancer},
  year={2014},
  volume={134 2},
  pages={437-44}
}
Genital infection with the oncogenic human papillomavirus is the necessary cause of cervical cancer and of a large fraction of vulvar cancers. The toll-like receptor and the nuclear factor κB (NF-κB) signaling pathways have been implicated in inflammation, autoimmune disease and cancer, but whether common nucleotide variation in these pathways is associated with the risk of cervical and vulvar cancers has received little study. Using data from a population-based case-control study of cervical… CONTINUE READING
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