Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis.

  title={Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis.},
  author={Ana M Valdes and Tim D. Spector and A. R. Tamm and Kalle V. Kisand and Sally A. Doherty and Elaine M. Dennison and Massimo Mangino and Ann E. Tamm and Irina Kerna and Deborah J. Hart and Margaret K Wheeler and Cyrus Cooper and Rik J. U. Lories and Nigel K Arden and Michael T. Doherty},
  journal={Arthritis and rheumatism},
  volume={62 8},
OBJECTIVE Smad3 (or, MADH3) is a key intracellular messenger in the transforming growth factor beta signaling pathway. In mice, Smad3 deficiency accelerates growth plate chondrocyte maturation and leads to an osteoarthritis (OA)-like disease. We undertook this study to investigate the role of genetic variation in SMAD3 in the risk of large-joint OA in humans. METHODS Ten tag single-nucleotide polymorphisms (SNPs) in the SMAD3 gene region were tested in a discovery set: 313 patients who had… CONTINUE READING
59 Citations
14 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 59 extracted citations


Publications referenced by this paper.
Showing 1-10 of 14 references

TGF- signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads

  • PM Van der Kraan, EN Blaney Davidson, A Blom, WB. van den Berg
  • Osteoarthritis Cartilage
  • 2009

Similar Papers

Loading similar papers…