Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility

  title={Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility},
  author={Rebecca Lynn Zuvich and Jacob L. McCauley and Jorge Oksenberg and Stephen J Sawcer and Philip L. De Jager and Cristin McCabe Aubin and Anne H. Cross and Laura Piccio and Neelum Thanik Aggarwal and Denis E Evans and David A. Hafler and Alastair D Compston and Stephen L. Hauser and Margaret A. Pericak-Vance and Jonathan L. Haines},
  journal={Human Genetics},
Multiple sclerosis (MS) is characterized as an autoimmune demyelinating disease. Numerous family studies have confirmed a strong genetic component underlying its etiology. After several decades of frustrating research, the advent and application of affordable genotyping of dense SNP maps in large data sets has ushered in a new era in which rapid progress is being made in our understanding of the genetics underlying many complex traits. For MS, one of the first discoveries to emerge in this new… CONTINUE READING