Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: the Rotterdam study.

@article{Vaes2009GeneticVI,
  title={Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: the Rotterdam study.},
  author={R B A Vaes and Fernando Rivadeneira and J. F. M. Kerkhof and Albert Hofman and Huib A. P. Pols and Andr{\'e} G. Uitterlinden and Joyce B. J. van Meurs},
  journal={Annals of the rheumatic diseases},
  year={2009},
  volume={68 11},
  pages={1754-60}
}
BACKGROUND A polymorphism (rs143383; T to C) near the GDF5 gene has been associated with height and osteoarthritis (OA), but debate exists about whether its primary biological action is directed to cartilage or bone. OBJECTIVE To study the association between genetic variation in the GDF5 region and radiographic osteoarthritis (ROA) susceptibility, height, bone size parameters and fracture risk in a large population-based cohort of Caucasian elderly subjects. METHODS 6365 men and women had… CONTINUE READING

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