Genetic variation in the CRP promoter: association with systemic lupus erythematosus.

@article{Edberg2008GeneticVI,
  title={Genetic variation in the CRP promoter: association with systemic lupus erythematosus.},
  author={Jeffrey C. Edberg and Jianming Wu and Carl D. Langefeld and Elizabeth E. Brown and Miranda C. Marion and Gerald McGwin and Michelle Petri and Rosalind Ramsey-Goldman and John D Reveille and Summer G Frank and Kenneth M Kaufman and John Barker Harley and Graciela S Alarc{\'o}n and Robert Kimberly},
  journal={Human molecular genetics},
  year={2008},
  volume={17 8},
  pages={1147-55}
}
The pentraxin C-reactive protein (CRP), an innate immune system opsonin which binds nuclear debris and apoptotic bodies, may protect against autoimmunity. A relative deficiency of CRP levels in patients with systemic lupus erythematosus (SLE) might contribute to altered handling of self-antigens. We report that the proximal 5' promoter region of CRP contains several polymorphisms that exhibit association with SLE in multiple populations. Strongest association was observed at the proximal… CONTINUE READING