Genetic variation in the COX-2 gene and the association with prostate cancer risk.

@article{Shahedi2006GeneticVI,
  title={Genetic variation in the COX-2 gene and the association with prostate cancer risk.},
  author={Katarina Shahedi and Sara Lindstr{\"o}m and S{\'i}qun Lilly Zheng and Fredik Wiklund and J. Patrik Adolfsson and Jielin Sun and Katarina Augustsson-B{\"a}lter and B-L Chang and H-O Adami and Wanli Liu and Henrik Gr{\"o}nberg and Jianfeng Xu},
  journal={International journal of cancer},
  year={2006},
  volume={119 3},
  pages={668-72}
}
COX-2 is a key enzyme in the conversion of arachidonic acid to prostaglandins. The prostaglandins produced by COX-2 are involved in inflammation and pain response in different tissues in the body. Accumulating evidence from epidemiologic studies, chemical carcinogen-induced rodent models and clinical trials indicate that COX-2 plays a role in human… CONTINUE READING