Genetic variation in the β1-adrenergic receptor is associated with the risk of atrial fibrillation after cardiac surgery.

@article{Jeff2014GeneticVI,
  title={Genetic variation in the β1-adrenergic receptor is associated with the risk of atrial fibrillation after cardiac surgery.},
  author={Janina M. Jeff and Brian S. Donahue and Kristin Brown-Gentry and Dan M. Roden and Dana C. Crawford and Charles M. Stein and Daniel Kurnik},
  journal={American heart journal},
  year={2014},
  volume={167 1},
  pages={101-108.e1}
}
BACKGROUND Postoperative atrial fibrillation (PoAF) after cardiac surgery is common and associated with increased morbidity and mortality. Increased sympathetic activation after surgery contributes to PoAF, and β-blockers are the first-line recommendation for its prevention. We examined the hypothesis that common functional genetic variants in the β1-adrenoreceptor, the mediator of cardiac sympathetic activation and drug target of β-blockers, are associated with the risk for PoAF and with the… CONTINUE READING
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