Genetic variation in strains of zebrafish (Danio rerio) and the implications for ecotoxicology studies

@article{Coe2009GeneticVI,
  title={Genetic variation in strains of zebrafish (Danio rerio) and the implications for ecotoxicology studies},
  author={Tobias S. Coe and Patrick B. Hamilton and Andrew M. Griffiths and David J. Hodgson and Mohammed Abdul Wahab and Charles R. Tyler},
  journal={Ecotoxicology},
  year={2009},
  volume={18},
  pages={144-150}
}
There is substantial evidence that genetic variation, at both the level of the individual and population, has a significant effect on behaviour, fitness and response to toxicants. Using DNA microsatellites, we examined the genetic variation in samples of several commonly used laboratory strains of zebrafish, Danio rerio, a model species in toxicological studies. We compared the genetic variation to that found in a sample of wild fish from Bangladesh. Our findings show that the wild fish were… 
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It is concluded that zebrafish stocks from the 6 different Brazilian fish farms present significant genetic and phenotypic variability and should be considered when carrying out work where reproductive rates are evaluated.
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The first large‐scale geographic analysis of genetic variation within and among wild zebrafish (Danio rerio) populations occurring in Nepal, India, and Bangladesh is conducted, and wild populations are genetically compared to several commonly used lab strains.
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TLDR
It is concluded that zebrafish stocks from the 6 different Brazilian fish farms present significant genetic and phenotypic variability and should be considered when carrying out work where reproductive rates are evaluated.
Genetic variation, inbreeding and chemical exposure—combined effects in wildlife and critical considerations for ecotoxicology
  • A. BrownD. Hosken C. Tyler
  • Biology, Environmental Science
    Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2009
TLDR
The relationships between genetic variation, inbreeding and chemical effects are critically discussed with the intention of seeking to support more effective chemical testing for the protection of wildlife.
Population‐level consequences for wild fish exposed to sublethal concentrations of chemicals – a critical review
TLDR
Molecular technologies, including microsatellite and SNP genotyping, and RNASeq for gene expression studies, are advancing understanding of mechanisms of eco-toxicological response, tolerance, adaptation and selection in wild populations, with examples including using microsatellites that has identified roach populations living in rivers contaminated with sewage effluents that are self-sustaining.
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