Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (the Swedish TIRA project).

@article{Kastbom2008GeneticVI,
  title={Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (the Swedish TIRA project).},
  author={Alf Kastbom and Deepak Verma and Per Eriksson and Thomas Skogh and Gun B Wingren and Peter S{\"o}derkvist},
  journal={Rheumatology},
  year={2008},
  volume={47 4},
  pages={
          415-7
        }
}
OBJECTIVES The genetic background to RA is incompletely understood. As new cytokine-targeted therapies emerge, early predictors of disease severity are becoming increasingly important. The inflammasomes are essential regulators of cytokine production. We investigated whether two polymorphisms in the genes encoding cryopyrin (CIAS1) and TUCAN (CARD8) influence susceptibility and disease course in RA. METHODS Genotype frequencies were assessed in 174 Swedish patients with early RA and 360… CONTINUE READING
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