Genetic variation in mouse apolipoprotein A-IV expression is determined pre- and post-transcriptionally.

@article{Reue1993GeneticVI,
  title={Genetic variation in mouse apolipoprotein A-IV expression is determined pre- and post-transcriptionally.},
  author={Karen Reue and DEBORAH A. PURCELL-HUYNH and Thomas H. Leete and Mark H. Doolittle and A Durstenfeld and Aldons J. Lusis},
  journal={Journal of lipid research},
  year={1993},
  volume={34 6},
  pages={893-903}
}
Among inbred mouse strains there is a striking genetic variation in the levels of apolipoprotein A-IV (apoA-IV) mRNA in the liver, although intestinal mRNA levels vary only twofold in these strains. In the present study we have characterized the apoA-IV expression phenotypes in strains C57BL/6J and 129/J, and investigated the molecular basis for the genetic variation. We report that the two strains differ eight- to tenfold both in the levels of apoA-IV mRNA and in the rate of apoA-IV protein… CONTINUE READING