• Corpus ID: 32616948

Genetic variation in miR-100 rs1834306 is associated with decreased risk for esophageal squamous cell carcinoma in Kazakh patients in northwest China.

@article{Zhu2015GeneticVI,
  title={Genetic variation in miR-100 rs1834306 is associated with decreased risk for esophageal squamous cell carcinoma in Kazakh patients in northwest China.},
  author={Jianbo Zhu and Lan Yang and Weiyan You and Xiao-bin Cui and Yun-zhao Chen and Jianming Hu and Wei Liu and Shugang Li and Xiaoyue Song and Yutao Wei and Wenjie Zhang and Feng Li},
  journal={International journal of clinical and experimental pathology},
  year={2015},
  volume={8 6},
  pages={
          7332-40
        }
}
  • Jianbo Zhu, Lan Yang, Feng Li
  • Published 1 June 2015
  • Biology
  • International journal of clinical and experimental pathology
MicroRNAs (miRNAs) are a family of small noncoding RNAs that act as oncogenes and tumor suppressors. Single nucleotide polymorphisms (SNPs) in miRNAs may be associated with changes in phenotype and function. The aim of this study was to verify whether genetic variations in candidate microRNA (miRNA or miR) genes could contribute to esophageal squamous cell carcinoma (ESCC) susceptibility. A case-control study in 248 Kazakh patients with ESCC and 300 frequency matched control subjects was… 

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References

SHOWING 1-10 OF 40 REFERENCES
A functional varient in microRNA-146a is associated with risk of esophageal squamous cell carcinoma in Chinese Han
MicroRNAs are a new class of non-proteincoding, small RNAs that function as tumor suppressors or oncogenes. They participate in diverse biological pathways and function as gene regulators. A G>C
MicroRNA sequence polymorphisms and the risk of different types of cancer
TLDR
Investigating the association between nine common MirSNPs and cancer risk using data from large scale case-control studies found they might affect an individual's susceptibility to various types of cancer.
MiR-196a2 rs11614913 T > C polymorphism and risk of esophageal cancer in a Chinese population.
A New Polymorphism Biomarker rs629367 Associated with Increased Risk and Poor Survival of Gastric Cancer in Chinese by Up-Regulated miRNA-let-7a Expression
Background Variant in pri-miRNA could affect miRNA expression and mature process or splicing efficiency, thus altering the hereditary susceptibility and prognosis of cancer. We aimed to assess
A genetic variant in miR-146a modifies colorectal cancer susceptibility in a Chinese population
TLDR
The results suggest that miR-146a rs2910164 may contribute to the susceptibility to CRC in a Chinese population, and larger population-based prospective and functional studies are needed to validate the findings.
Genetic Variations in MicroRNA-Related Genes Are Novel Susceptibility Loci for Esophageal Cancer Risk
TLDR
The present study provides the first evidence that miRNAs may affect esophageal cancer risk in general and that specific genetic variants in miRNA-related genes may affect the risk individually and jointly.
Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan
TLDR
It is suggested that miRNA polymorphic variants might be useful predictors of clinical outcome in mCRC patients treated with 5-fluorouracil and CPT-11 combination and in the miRNA-biogenesis pathway.
Two common SNPs in pri-miR-125a alter the mature miRNA expression and associate with recurrent pregnancy loss in a Han-Chinese population
TLDR
The data collectively suggest that two common polymorphisms in pre-miR-125a might contribute to the genetic predisposition to RPL by disrupting the production of miR- 125a, which consequently interfered in the expression and function of target genes of MiRNAs, including LIFR and ERBB2.
A functional variation in pre-microRNA-196a is associated with susceptibility of esophageal squamous cell carcinoma risk in Chinese Han
  • Kai Wang, Hong Guo, Yun Bai
  • Biology, Medicine
    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
  • 2010
TLDR
A genetic association study between the SNP (rs11614913) in pre-miRNA-196a and esophageal squamous cell carcinoma (ESCC) susceptibility in a case–control study found that the homozygote CC of this SNP increased the risk of ESCC compared with thehomozygote TT and the risk was more evident among smokers than non-smokers.
...
1
2
3
4
...