Genetic variation in insulin receptor β-chain exons among members of familial Type 2 (non-insulin-dependent) diabetic pedigrees

@article{Elbein1991GeneticVI,
  title={Genetic variation in insulin receptor β-chain exons among members of familial Type 2 (non-insulin-dependent) diabetic pedigrees},
  author={S. C. Elbein and L. Sorensen},
  journal={Diabetologia},
  year={1991},
  volume={34},
  pages={742-749}
}
Insulin resistance appears to be an essential component of Type 2 (non-insulin-dependent) diabetes mellitus. Both hyperinsulinaemia and insulin resistance are inherited and may precede the onset of Type 2 diabetes. To determine whether insulin receptor gene mutations, and specifically whether mutations of the β-chain could account for the observed insulin resistance, we studied members of 16 pedigrees ascertained for two or more Type 2 diabetic siblings and members of four additional pedigrees… CONTINUE READING

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