Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy.

@article{Hoffjan2004GeneticVI,
  title={Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy.},
  author={Sabine Hoffjan and Irina Ostrovnaja and Dan L. Nicolae and Dina L Newman and Raluca I Nicolae and Ronald E. Gangnon and Lori Steiner and Karen P. Walker and Rebecca Reynolds and Deborah Greene and Daniel B. Mirel and James E Gern and Robert F. Lemanske and Carole Ober},
  journal={The Journal of allergy and clinical immunology},
  year={2004},
  volume={113 3},
  pages={511-8}
}
BACKGROUND Asthma is a chronic respiratory disease that often originates in early childhood. Although candidate gene studies have identified many potential asthma susceptibility genes in adult populations, few have studied associations with immune phenotypes in the first year that might be early clinical markers of asthma. OBJECTIVE The aim of this study was to assess the contribution of genetic variation to cytokine response profiles and atopic phenotypes in the first year of life in the… CONTINUE READING
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