Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk

  title={Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk},
  author={Daniele Campa and James Mckay and Olga Sinilnikova and Anika Huesing and Ulla Vogel and Rikke Dalgaard Hansen and Kim Overvad and Petra Mariann Witt and Francoise Clavel-Chapelon and Marie-Christine Boutron-Ruault and V{\'e}ronique Chaj{\`e}s and Sabine Rohrmann and Jenny Chang-Claude and H. B{\"o}ing and Eva Z Fisher and Antonia Trichopoulou and Dimitirios Trichopoulos and Domenico Palli and Anna Villarini and Carlotta Sacerdote and Amalia Mattiello and Rosario Tumino and Petra H. M. Peeters and Carla H. van Gils and Hendrik Bas Bueno-de-Mesquita and Eiliv Lund and M D Chirlaque and N{\'u}ria Sala and Laudina Rodr{\'i}guez Su{\'a}rez and Aurelio Barricarte and Miren Dorronsoro and M P{\'e}rez S{\'a}nchez and Per Lenner and G{\"o}ran Hallmans and Kostas Tsilidis and Sheila Bingham and Kay-tee Khaw and Valentina Gallo and Teresa Norat and Elio Riboli and Sabina Rinaldi and Gilbert M. Lenoir and Sean V. Tavtigian and Frederico Canzian and Rudolf Kaaks},
  journal={Breast Cancer Research and Treatment},
Fatty acid synthase (FAS) is the major enzyme of lipogenesis. It catalyzes the NADPH-dependent condensation of acetyl-CoA and malonyl-CoA to produce palmitic acid. Transcription of the FAS gene is controlled synergistically by the transcription factors ChREBP (carbohydrate response element-binding protein), which is induced by glucose, and SREBP-1 (sterol response element-binding protein-1), which is stimulated by insulin through the PI3K/Akt signal transduction pathway. We investigated whether… CONTINUE READING


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