Genetic variation in dopaminergic neuromodulation influences the ability to rapidly and flexibly adapt decisions.

@article{Krugel2009GeneticVI,
  title={Genetic variation in dopaminergic neuromodulation influences the ability to rapidly and flexibly adapt decisions.},
  author={Lea K. Krugel and Guido Biele and Peter N. C. Mohr and Shu-Chen Li and Hauke R. Heekeren},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 42},
  pages={17951-6}
}
The ability to rapidly and flexibly adapt decisions to available rewards is crucial for survival in dynamic environments. Reward-based decisions are guided by reward expectations that are updated based on prediction errors, and processing of these errors involves dopaminergic neuromodulation in the striatum. To test the hypothesis that the COMT gene Val(158)Met polymorphism leads to interindividual differences in reward-based learning, we used the neuromodulatory role of dopamine in signaling… CONTINUE READING
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