Genetic variation in cytochrome P450 2J2 and soluble epoxide hydrolase and risk of ischemic stroke in a Chinese population.

@article{Zhang2008GeneticVI,
  title={Genetic variation in cytochrome P450 2J2 and soluble epoxide hydrolase and risk of ischemic stroke in a Chinese population.},
  author={Laxi Zhang and Hu Ding and Jiangtao Yan and Rutai Hui and Wei Wang and Grace E. Kissling and Darryl C. Zeldin and Dao Wen Wang},
  journal={Pharmacogenetics and genomics},
  year={2008},
  volume={18 1},
  pages={45-51}
}
OBJECTIVE Epoxyeicosatrienoic acids have been recognized for their protective effects on the cardiovascular system. This study investigated whether two common polymorphisms in genes believed to be influential in regulating circulating levels of epoxyeicosatrienoic acids, namely cytochrome P450 2J2 (CYP2J2) G-50T and soluble epoxide hydrolase (EPHX2) G860A, were associated with ischemic stroke risk in a Chinese population. METHODS AND RESULTS Screening of 200 patients with ischemic stroke and… CONTINUE READING

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