Genetic variation in bone growth patterns defines adult mouse bone fragility.

@article{Price2005GeneticVI,
  title={Genetic variation in bone growth patterns defines adult mouse bone fragility.},
  author={Christopher R. Price and Brad C Herman and Thomas Lufkin and Haviva M. Goldman and K J Leni Jepsen},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2005},
  volume={20 11},
  pages={
          1983-91
        }
}
UNLABELLED Femoral morphology and composition were determined for three inbred mouse strains between ages E18.5 and 1 year. Genotype-specific variation in postnatal, pubertal, and postpubertal growth patterns and mineral accrual explained differences in adult bone trait combinations and thus bone fragility. INTRODUCTION Fracture risk is strongly regulated by genetic factors. However, this regulation is generally considered complex and polygenic. Therefore, the development of effective genetic… CONTINUE READING
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