Genetic variation in angiotensin-converting enzyme does not prevent development of cardiac hypertrophy or upregulation of angiotensin II in response to aortocaval fistula.

@article{Perry2001GeneticVI,
  title={Genetic variation in angiotensin-converting enzyme does not prevent development of cardiac hypertrophy or upregulation of angiotensin II in response to aortocaval fistula.},
  author={Gilbert J. Perry and Tomohisa Mori and Chih Chang Wei and Xiao Yun Xu and Yunjia Chen and Suzanne Oparil and Pamela A. Lucchesi and Louis J. Dell'Italia},
  journal={Circulation},
  year={2001},
  volume={103 7},
  pages={1012-6}
}
BACKGROUND Experimental and clinical evidence suggests that angiotensin II may be an important mediator of cardiac hypertrophy in response to hemodynamic stress. We investigated the effect of genetic variation in angiotensin-converting enzyme (ACE) on the development of cardiac hypertrophy and left ventricular (LV) dysfunction in response to volume overload. METHODS AND RESULTS Male heterozygous ACE knockout (1/0) and wild-type (1/1) mice were studied 4 weeks after the creation of an… CONTINUE READING

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References

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Showing 1-10 of 30 references

Blood and cardiovascular homeostasis in mice having reduced or absent angiotensin - converting enzyme gene function

  • JH Krege, HS Kim, JS Moyer
  • Hypertension
  • 1997

Blood and cardiovascular homeostasis in mice having reduced or absent angiotensin-converting enzyme gene function.Hypertension

  • B Tian, QC Meng, Y Chen
  • 1997

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