Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish.

@article{Damcott2005GeneticVI,
  title={Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish.},
  author={Coleen M. Damcott and Sandra H. Ott and Toni Pollin and Laurie J Reinhart and Jian Wang and Jeffrey R. O'Connell and Braxton D. Mitchell and Alan R. Shuldiner},
  journal={Diabetes},
  year={2005},
  volume={54 7},
  pages={2245-50}
}
Adiponectin receptor 1 (ADIPOR1) and adiponectin receptor 2 (ADIPOR2) are newly identified receptors for adiponectin, an adipocytokine with anti-inflammatory and insulin-sensitizing properties. We screened for polymorphisms by performing sequence analysis on all eight exons, splice junctions, and approximately 2 kb of the 5' flanking regions of each receptor. We detected 5 single nucleotide polymorphisms (SNPs) in ADIPOR1 and 16 SNPs in ADIPOR2. We genotyped these SNPs in Amish subjects with… CONTINUE READING

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