Genetic variation in Toll-like receptors and disease susceptibility

  title={Genetic variation in Toll-like receptors and disease susceptibility},
  author={M. Netea and C. Wijmenga and L. O’Neill},
  journal={Nature Immunology},
  • M. Netea, C. Wijmenga, L. O’Neill
  • Published 2012
  • Biology, Medicine
  • Nature Immunology
  • Toll-like receptors (TLRs) are key initiators of the innate immune response and promote adaptive immunity. Much has been learned about the role of TLRs in human immunity from studies linking TLR genetic variation with disease. First, monogenic disorders associated with complete deficiency in certain TLR pathways, such as MyD88-IRAK4 or TLR3-Unc93b-TRIF-TRAF3, have demonstrated the specific roles of these pathways in host defense against pyogenic bacteria and herpesviruses, respectively. Second… CONTINUE READING
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