Genetic variation in Th1/Th2 pathway genes and risk of non-Hodgkin lymphoma: a pooled analysis of three population-based case-control studies.

@article{Lan2011GeneticVI,
  title={Genetic variation in Th1/Th2 pathway genes and risk of non-Hodgkin lymphoma: a pooled analysis of three population-based case-control studies.},
  author={Qing Lan and Sophia Wang and Idan Menashe and Bruce Konrad Armstrong and Yawei Zhang and Patricia A Hartge and Mark P Purdue and Theodore Holford and Lindsay McOmber Morton and Anne Kricker and James R. Cerhan and Andrew Edwin Grulich and Wendy Cozen and Shelia Hoar Zahm and Meredith Yeager and Claire M Vajdic and Maryjean Schenk and Brian P. Leaderer and Jeff Yuenger and Richard K. Severson and Nilanjan Chatterjee and Stephen J. Chanock and Tongzhang Zheng and Nathaniel Rothman},
  journal={British journal of haematology},
  year={2011},
  volume={153 3},
  pages={
          341-50
        }
}
The balance between T-helper 1 (Th1) and T-helper 2 (Th2) activity is critical in lymphoid cell development and differentiation. Immune dysfunction underlies lymphomagenesis, so an alteration in the regulation of key Th1/Th2 cytokines may lead to the development of non-Hodgkin lymphoma (NHL). To study the impact of polymorphisms in Th1/Th2 cytokines on NHL risk, we analyzed 145 tag single nucleotide polymorphisms (SNPs) in 17 Th1/Th2 cytokine and related genes in three population-based case… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

IL12Rβ1: the cytokine receptor that we used to know.

Cytokine • 2015
View 8 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…