Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium.

@article{Kelemen2010GeneticVI,
  title={Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium.},
  author={Linda E. Kelemen and Marc T. Goodman and Valerie A McGuire and Mary Anne Rossing and Penelope M Webb and Martin K{\"o}bel and Hoda Anton-Culver and Jonathan Beesley and Andrew Berchuck and Sony S Brar and Michael E. Carney and Jenny Chang-Claude and Georgia Chenevix-Trench and Daniel W Cramer and Julie M Cunningham and Richard A. Dicioccio and Jennifer A Doherty and Douglas F. Easton and Zachary S. Fredericksen and Brooke L. Fridley and Margaret A. Gates and Simon A. Gayther and Aleksandra Gentry-Maharaj and Estrid V. S. H\ogdall and Susanne Kr{\"u}ger Kjaer and Galina Lurie and Usha Menon and Patricia G. Moorman and Kirsten B Moysich and Roberta B. Ness and Rachel T. Palmieri and Celeste Leigh Pearce and Paul P. D. Pharoah and Susan J Ramus and Honglin Song and Daniel O. Stram and Shelley S Tworoger and David J. Van Den Berg and Robert A Vierkant and Shan Wang-gohrke and Alice S. Whittemore and Lynne Ross Wilkens and Anna H Wu and Joellen Martha Schildkraut and Thomas A. Sellers and Ellen L. Goode},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2010},
  volume={19 7},
  pages={1822-30}
}
BACKGROUND We previously reported the risks of ovarian carcinoma for common polymorphisms in one-carbon transfer genes. We sought to replicate associations for DPYD rs1801265, DNMT3A rs13420827, MTHFD1 rs1950902, MTHFS rs17284990, and TYMS rs495139 with risk of ovarian carcinoma overall and to use the large sample of assembled cases to investigate associations by histologic type. METHODS Associations were evaluated in the Ovarian Cancer Association Consortium, including 16 studies of 5,593… CONTINUE READING
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