Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis.

@article{Soerensen2012GeneticVI,
  title={Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis.},
  author={Mette Soerensen and Mikael Thinggaard and Marianne Nygaard and Serena Dato and Qihua Tan and Jacob V B Hjelmborg and Karen Andersen-Ranberg and Tinna Stevnsner and Vilhelm A. Bohr and Masayuki Kimura and Abraham Aviv and Kaare Christensen and Lene Christiansen},
  journal={Aging cell},
  year={2012},
  volume={11 2},
  pages={223-7}
}
Telomerase is of key importance for telomere maintenance, and variants of the genes encoding its major subunits, telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC), are candidates for interindividual variation in telomere length. Recently, the two SNPs rs3772190 and rs12696304 in the TERC locus were reported to be associated with leukocyte telomere length (LTL) in two genome-wide association studies, while one haplotype of TERT (rs2853669, rs2736098, rs33954691, and… CONTINUE READING
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