Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission.

@article{Beard2000GeneticVI,
  title={Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission.},
  author={Charles Ben Beard and J. L. Carter and Scott P Keely and Laurence Huang and Norman J. Pieniazek and Iaci N S Moura and Jacquelin M. Roberts and Allen W. Hightower and Marcelle Bens and Abigail R Freeman and S. Lee and James R. Stringer and Jeffrey S. Duchin and Carlos Del Rio and David Rimland and Robert P Baughman and Deborah A. Levy and Vance J Dietz and Ph. Simon and Thomas R. Navin},
  journal={Emerging Infectious Diseases},
  year={2000},
  volume={6},
  pages={265 - 272}
}
To study transmission patterns of Pneumocystis carinii pneumonia (PCP) in persons with AIDS, we evaluated P. carinii isolates from patients in five U.S. cities for variation at two independent genetic loci, the mitochondrial large subunit rRNA and dihydropteroate synthase. Fourteen unique multilocus genotypes were observed in 191 isolates that were examined at both loci. Mixed infections, accounting for 17.8% of cases, were associated with primary PCP. Genotype frequency distribution patterns… CONTINUE READING
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