Genetic variation in NOS1AP is associated with sudden cardiac death: evidence from the Rotterdam Study.

@article{Eijgelsheim2009GeneticVI,
  title={Genetic variation in NOS1AP is associated with sudden cardiac death: evidence from the Rotterdam Study.},
  author={Mark Eijgelsheim and Christopher H. Newton-Cheh and Adrianus L H J Aarnoudse and Charlotte van Noord and Jacqueline C. M. Witteman and Albert Hofman and Andr{\'e} G. Uitterlinden and Bruno C. Stricker},
  journal={Human molecular genetics},
  year={2009},
  volume={18 21},
  pages={4213-8}
}
Common variation within the nitric oxide-1 synthase activator protein (NOS1AP) locus is strongly related to QT interval, a sudden cardiac death (SCD) risk factor. A recent report describes common variation in NOS1AP associated with SCD in a US population of European ancestry. The objective of the current study was to obtain additional evidence by investigating the association between NOS1AP variants and SCD in the prospective population-based Rotterdam Study. The study population consisted of… CONTINUE READING

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