Genetic variation in MHC class II expression and interactions with MHC sequence polymorphism in three‐spined sticklebacks

@article{Wegner2006GeneticVI,
  title={Genetic variation in MHC class II expression and interactions with MHC sequence polymorphism in three‐spined sticklebacks},
  author={Karl Mathias Wegner and Martin Kalbe and Gisep Rauch and Joachim Kurtz and Helmut Schaschl and Thorsten B. H. Reusch},
  journal={Molecular Ecology},
  year={2006},
  volume={15}
}
Genes of the major histocompatibility complex (MHC) have been studied for several decades because of their pronounced allelic polymorphism. Structural allelic polymorphism is, however, not the only source of variability subjected to natural selection. Genetic variation may also exist in gene expression patterns. Here, we show that in a natural population of three‐spined sticklebacks (Gasterosteus aculeatus) the expression of MHC class IIB genes was positively correlated with parasite load… Expand
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Characterization, Polymorphism, and Evolution of MHC Class II B Genes in Birds of Prey
TLDR
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Contrasting mode of evolution between the MHC class I genomic region and class II region in the three-spined stickleback (Gasterosteus aculeatus L.; Gasterosteidae: Teleostei)
TLDR
It seems that interlocus recombination may play a rather minor role in generating class I diversity in stickleback and that the class I region displays a higher genomic stability (i.e., lower local recombination rate) than the class II region. Expand
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TLDR
It was found that sticklebacks with low MHC diversity suffered more from parasite infection after experimental exposure to Schistocephalus solidus tapeworms and Glugea anomala microsporidians, and showed the highest proportion of granulocytes and the strongest respiratory burst reaction, which are correlates of innate immunity. Expand
Multiple parasites are driving major histocompatibility complex polymorphism in the wild
Abstract Parasite mediated selection may result in arms races between host defence and parasite virulence. In particular, simultaneous infections from multiple parasite species should causeExpand
Inter- and Intralocus Recombination Drive MHC Class IIB Gene Diversification in a Teleost, the Three-Spined Stickleback Gasterosteus aculeatus
TLDR
The finding of widespread recombination suggests that phylogenies of MHC genes should not be based on coding segments but rather on noncoding introns, and nonindependence of molecular evolution across loci and frequent recombination suggest that MHC class II genes of bony fish may follow different evolutionary dynamics than those of mammals. Expand
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TLDR
This study tested whether three-spined sticklebacks carrying an intermediate level of individual MHC diversity also displayed the strongest level of resistance against parasite infection, and found a significant minimal mean infection rate at an intermediate number of MHC class IIB variants. Expand
Association between major histocompatibility complex class IIB alleles and resistance to Aeromonas salmonicida in Atlantic salmon
TLDR
The hypothesis that MHC polymorphism is maintained through pathogen–driven selection acting by means of frequency–dependent selection rather than heterozygous advantage is supported. Expand
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TLDR
A comparison of nonsynonymous and synonymous substitutions between the peptide binding region codons and non-peptide binding regions codons of these sequences revealed that they are under strong selective pressure. Expand
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TLDR
The contribution to the constitutive and cytokine-induced expression of MHC class I and II genes of MHS class-specific regulatory elements and regulatory elements which apparently are shared by the promoters of M HC classI and class II genes are addressed. Expand
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TLDR
Overall, the evidence is compelling that the MHC currently represents the best system available in vertebrates to investigate how natural selection can promote local adaptation at the gene level despite the counteracting actions of migration and genetic drift. Expand
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TLDR
MHC genotype did not significantly influence parasite load, and genomic background explained a significant percentage of the variation in parasite load. Expand
Recent duplication and inter-locus gene conversion in major histocompatibility class II genes in a teleost, the three-spined stickleback
TLDR
Using a bacterial artificial chromosome library, a 99.5 kb genomic segment containing the major histocompatibility class II genes of a teleost, the three-spined stickleback Gasterosteus aculeatus, is analysed and a 10- to 20-fold higher frequency of CpG-islands on the MH class II segment compared to other species, a feature that may be conducive for inter-locus recombination. Expand
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