Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

@article{Ge2009GeneticVI,
  title={Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance},
  author={Dongliang Ge and Jacques Fellay and Alexander J Thompson and Jason S. Simon and Kevin V. Shianna and Thomas J. Urban and Erin L. Heinzen and Ping Qiu and Arthur H. Bertelsen and Andrew J. Muir and Mark S. Sulkowski and John McHutchison and David B. Goldstein},
  journal={Nature},
  year={2009},
  volume={461},
  pages={399-401}
}
Chronic infection with hepatitis C virus (HCV) affects 170 million people worldwide and is the leading cause of cirrhosis in North America. Although the recommended treatment for chronic infection involves a 48-week course of peginterferon-α-2b (PegIFN-α-2b) or -α-2a (PegIFN-α-2a) combined with ribavirin (RBV), it is well known that many patients will not be cured by treatment, and that patients of European ancestry have a significantly higher probability of being cured than patients of African… 

HEPATOLOGY ELSEWHERE EDITORSKris Kowdley , Seattle , WA

TLDR
It is reported that a genetic polymorphism near the IL28B gene, encoding interferon- lambda-3 (IFN-lambda-3), is associated with an approximately twofold change in response to treatment, both among patients of European ancestry and African-Americans.

IL28B polymorphism and genetic biomarkers of viral clearance in hepatitis C virus infection.

TLDR
A association between genetic variation in the region of the IL28B gene and treatment outcome in HCV-1 patients and patients who carry the good response variant are two- to three-fold more likely to be cured.

The Role of Pharmacogenetics in the Treatment of Chronic Hepatitis C Infection

TLDR
The pharmacogenetic data for boceprevir and telaprevir triple therapy in patients with HCV‐1 infection, as well as viral genomic polymorphisms and genetic variants that may protect against anemia are reviewed.

Pharmacogenetics: A SNP for hepatitis C treatment failure

  • C. V. Ooij
  • Medicine, Biology
    Nature Reviews Genetics
  • 2009
TLDR
In patients who have the marker that is associated with treatment failure, the levels of IL28 mRNA in the blood were significantly lower than in individuals who did not carry the marker, which suggests that the causal variants might affect the expression of this gene.

Immunologic al and Genetic Markers Predicting Treatment Outcome in Hepatitis C Virus Infection

TLDR
The specific sCD26 activity was found to predict the effectiveness of peg-IFN/RBV therapy in chronic hepatitis C, and enhance the value of established outcome predictors.

IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C.

IL28B polymorphism, Explanation for Different Responses to Therapy in Hepatitis C Patients

TLDR
SVR as a hepatitis C treatment outcome can be predicted by various baseline predictors such as HCV RNA levels, the dose and duration of therapy, body mass index, age, insulin resistance, gender, stage of fibrosis and co-infection with other hepatitis viruses or HIV.

Genetics of IL28B and HCV—response to infection and treatment

TLDR
Current understanding of the role of IL28B in HCV infection and response to therapy is summarized and hepatic expression levels ofIL28B and interferon-stimulated genes seem to be reduced at baseline, but are induced more strongly after IFN-α administration, perhaps resulting in more effective elimination of the virus.

Individualized Therapy for Hepatitis C Infection: Focus on the Interleukin-28B Polymorphism in Directing Therapy

TLDR
In the era of increased overall virologic response rates and good tolerability of the rapidly developing non-IFN oral direct-acting antiviral therapy regimens, the need for individualized treatment is likely to diminish and various predictors of response, including IL28B will likely be of reduced importance in the near future.
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TLDR
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