Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

@article{Ge2009GeneticVI,
  title={Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance},
  author={D. Ge and J. Fellay and A. Thompson and J. Simon and K. Shianna and T. Urban and E. Heinzen and P. Qiu and A. Bertelsen and A. Muir and M. Sulkowski and J. McHutchison and D. Goldstein},
  journal={Nature},
  year={2009},
  volume={461},
  pages={399-401}
}
Chronic infection with hepatitis C virus (HCV) affects 170 million people worldwide and is the leading cause of cirrhosis in North America. Although the recommended treatment for chronic infection involves a 48-week course of peginterferon-α-2b (PegIFN-α-2b) or -α-2a (PegIFN-α-2a) combined with ribavirin (RBV), it is well known that many patients will not be cured by treatment, and that patients of European ancestry have a significantly higher probability of being cured than patients of African… Expand
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HEPATOLOGY ELSEWHERE EDITORSKris Kowdley , Seattle , WA
Chronic infection with hepatitis C virus (HCV) affects 170 million people worldwide and is the leading cause of cirrhosis in North America. Although the recommended treatment for chronic infection… Expand
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Current understanding of the role of IL28B in HCV infection and response to therapy is summarized and hepatic expression levels ofIL28B and interferon-stimulated genes seem to be reduced at baseline, but are induced more strongly after IFN-α administration, perhaps resulting in more effective elimination of the virus. Expand
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References

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The data suggest that host genetics may be useful for the prediction of drug response, and they also support the investigation of the role of IL28B in the treatment of HCV and in other diseases treated with IFN-α. Expand
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It is shown that the C/C genotype strongly enhances resolution of HCV infection among individuals of both European and African ancestry, the strongest and most significant genetic effect associated with natural clearance ofHCV. Expand
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TLDR
In treatment-naive Asian patients with HCV-1 infection, 48 weeks of pegylated IFN-alpha-2a plus ribavirin therapy is associated with a higher SVR rate, compared with 24 weeks of such therapy. Expand
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